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Issue:ISSN 1000-7083
          CN 51-1193/Q
Director:Sichuan Association for Science and Technology
Sponsored by:Sichuan Society of Zoologists; Chengdu Giant Panda Breeding Research Foundation; Sichuan Association of Wildlife Conservation; Sichuan University
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Your Position :Home->Past Journals Catalog->2013 Vol.32 No.1

Effects of the Suaeda rigida Polysaccharides on NO Content and NOS Activity in the Serum of Immunosuppressed Mice
Author of the article:SHA Ai-long, YANG Xue-ping, WANG Wei, CHANG Chen-chen, PANG Jun
Author's Workplace:(College of Animal Science, Key Laboratory of Animal Husbandry Science and Technology of Xinjiang Production and Construction Corps, Tarim University, Alar, Xinjiang Uygur Autonomous Region 843300, China)
Key Words:Suaeda rigida polysaccharides; immunosuppressed mice; nitric oxide; nitric oxide synthase
Abstract:The study was carried out to investigate the content of nitric oxide (NO), the activities of total nitric oxide synthase (TNOS) and induced nitric oxide synthase (iNOS) in the serum of mice treated with hydrocortisone in vivo by subcutaneous injection together with the Suaeda rigida polysaccharides at doses of 100, 200 and 400 mg/kg•d. The results showed that in the immunosuppressive serum of the 3 test groups, the content of NO was significantly reduced and so were the activities of TNOS and iNOS. In the lower and intermediate concentration groups of the Suaeda rigida polysaccharides, iNOS activity was significantly lower than that of the model control group (P<0.05), and in the higher one, it was significantly lower (P<0.01); In every test group, the content of NO and the activity of TNOS were very different from the model control group (P<0.01), significantly depending on concentrations. The results indicated that the Suaeda rigida polysaccharides could protect cells and enhance the immunity of mice with an antioxidation activity by controlling the content of NO and the activities of TNOS and iNOS which involved in production and elimination of free radicals in immunosuppressed mice.
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