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Issue:ISSN 1000-7083
          CN 51-1193/Q
Director:Sichuan Association for Science and Technology
Sponsored by:Sichuan Society of Zoologists; Chengdu Giant Panda Breeding Research Foundation; Sichuan Association of Wildlife Conservation; Sichuan University
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Your Position :Home->Past Journals Catalog->2012 Vol.31 No.5

Effects of Puerarin on Hemorheology and Renal Hemodynamics in Rabbits with Glycerine-induced Acute Renal Failure
Author of the article:ZHANG Chun-mei, CHEN Rong, TANG Hua, WANG Shun-rong, HUANG Po, LI Zhu-hua*
Author's Workplace:(Department of Pathophysiology, Luzhou Medical College, Luzhou, Sichuan Province 646000, China)
Key Words:puerarin; acute renal failure; hemorheology; renal blood flow
Abstract:

Objective  To investigate the effects of puerarin on hemorheology and renal hemodynamics in rabbits with glycerine-acute renal failure. Methods  30 male rabbits were used and divided into 5 groups randomly: (1) Normal group; (2)ARF group, acute renal failure induced by glycerine; (3) Pue 1 group, inject puerarin intravenously in a dose of 20 mg/kg after ARF(4) Pue 2 group, puerarin treated in a dose of 40 mg/kg after ARF(5) Pue 3 group, puerarin treated in a dose of 80 mg/kg after ARFThe following indices of each group were measured at various times, including hemorheology, renal blood flow (RBF), blood urea nitrogen (BUN) and serum creatinine levels (Cr). At last, left kidneys were harvested for histopathological examination. Results  Pue 2 group and Pue 3 group showed significantly decreased level of hemorheology, as well as Cr and BUN and increased level of RBF compared with ARF group (P<0.05). Histopathological examination showed that the swelling of renal tubular epithelial cell was lightened and cast formation was reduced obviously. Conclusion  Puerarin would improve hemodynamics and increase renal blood flow in order to improve renal function and reduce tubular injury.

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