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Issue:ISSN 1000-7083
          CN 51-1193/Q
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Your Position :Home->Past Journals Catalog->2012 Vol.31 No.4

The Molecular Markers and Regulation of Spermatogonial Stem Cells
Author of the article:YU Ping1, HUA Jin-lian1,2,3*
Author's Workplace:(1. College of Veterinary Medicine, Northwest Agriculture and Forestry University, Yangling, Shaanxi Province 712100, China; 2. Shaanxi Center of Stem Cells Engineering and Technology, Yangling, Shaanxi Province 712100, China; 3. Key Lab for Animal Biotechnology of Agriculture Ministry of China, Yangling, Shaanxi Province 712100, China)
Key Words: spermatogonial stem cells (SSCs); regulatory mechanism;self-renewal; differentiation
Abstract:Spermatogonial stem cells (SSCs) are the foundation of spermatogenesis, a group of cells which live in a specialized niche and have multiple differentiation potentiality. Recently, α6- and β-integrin, CD9, GFRA1 and other main molecular makers are regarded as the specific markers of SSCs, as well as the discovery of a variety of cytokines and genes, such as GDNF, PLZF, ubiquitin, LIF, which determine the self-renewal and differentiation of SSCs. New achievements have been reached on SSCs separation, identification and biological characteristics. This paper reviews the main molecular makers and regulatory mechanism of self-renewal and differentiation of SSCs at present, and provides further guidance for future studies of other stem cells.
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