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Issue:ISSN 1000-7083
          CN 51-1193/Q
Director:Sichuan Association for Science and Technology
Sponsored by:Sichuan Society of Zoologists; Chengdu Giant Panda Breeding Research Foundation; Sichuan Association of Wildlife Conservation; Sichuan University
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Your Position :Home->Past Journals Catalog->2012 Vol.31 No.1

The Effect of Manna Oligosaccharides and Chitosan on Blood Glucose and Lipids Levels in Diabetic Mice by Alloxan
Author of the article:GAO Qi-yu1, XU Guang-cui2, JIANG Yuan-yuan1
Author's Workplace:(1. Department of Life Science and Technology, Xinxiang Medical College, Xinxiang, Henan Province 453003, China; 2. Department of Public Health, Xinxiang Medical College, Xinxiang, Henan Province 453003, China)
Key Words:manna oligosaccharides;chitosan;blood glucose;blood lipids
Abstract:Objective  To investigate the hypoglycemic effect of manna oligosaccharides and chitosan on blood glucose and lipids levels in diabetic mice. Methods  Diabetic 70 healthy mice were selected randomly, then ten diabetic mice were fed with basic diet. While the others were injected alloxan (150 mg/kg) into the abdominal cavity to induce diabetic model. After 48 h, determines the blood glucose value with the fast glucometer, those mice whose blood glucose value >11.1 mmol/L were diabetic mice. The diabetic mice were randomly divided into five groups: model control, high and low dose manna oligosaccharides treatment group, high and low dose chitosan treatment group. The normal and the model control groups were set up at the same time and given equal volume 0.75% NaCl. After 12 d, determines the Glucose (GLU), total Cholesterol (CHO), High Density Lipoprotein Cholesterol (HDL-C) and the Triglyceride (TG) density. The blood glucose of manna oligosaccharides and chitosan groups decreased significantly contrast to model control group. CHO, TG decreased and HDL-C increased prominently. Results  The results indicated that higher-treatment is better that lower-treatment on deceasing blood glucose and blood lipids.
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