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Issue:ISSN 1000-7083
          CN 51-1193/Q
Director:Sichuan Association for Science and Technology
Sponsored by:Sichuan Society of Zoologists; Chengdu Giant Panda Breeding Research Foundation; Sichuan Association of Wildlife Conservation; Sichuan University
Address:College of Life Sciences, Sichuan University, No.29, Wangjiang Road, Chengdu, Sichuan Province, 610064, China
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Your Position :Home->Past Journals Catalog->2006 Vol.25 No.3

Study of Establishing Myocardial Infarction Model of Mice
Author of the article:ZHAO Xiao-hui, ZHOU Jian, MA Rui-yan, CHENG Wei, YANG Yong-yao, TIAN Ying, FANG Yong-qiang, HUANG La
Author's Workplace:(Departments of Cardiovascular, Xinqiao Hospital, Third Military Medical University, Chongqing 400037)
Key Words:myocardial infarction; animal model; mouse
Objective  To establish myocardial infarction model in mice. Method 40 mice were anesthetized with pentobarbital sodium. The wire of percutaneous transluminal coronary angioplasty (PTCA) was retrogressed to oral cavity through trachea by which the tracheal intubation was guided. Then the chest was opened and left anterior descending coronary artery was ligated. Result The operation was successfully finished in all mice. There were 38 mice survival after 1 day and 32 mice alive after 2 weeks. Conclusion The myocardial infarction model could be effectively imitated through this method.
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