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Issue:ISSN 1000-7083
          CN 51-1193/Q
Director:Sichuan Association for Science and Technology
Sponsored by:Sichuan Society of Zoologists; Chengdu Giant Panda Breeding Research Foundation; Sichuan Association of Wildlife Conservation; Sichuan University
Address:College of Life Sciences, Sichuan University, No.29, Wangjiang Road, Chengdu, Sichuan Province, 610064, China
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Your Position :Home->Past Journals Catalog->2011 Vol.30 No.2

Immunosuppressive Effects of Pyrrosia lingua (Thunb.) Farwell on Immune Function and Rejection of Allogenetic Skin Transplantation in Mice
Author of the article:JIA Yong-fang, LI Li, ZHANG Tong, ZHANG Shun-li*
Author's Workplace:(College of Life Science, Henan Normal University, Xinxiang, Henan Province 453007, China)
Key Words:Pyrrosia lingua (Thunb.) Farwell; immune function; allogenetic skin transplantation; immunosuppression; mice
Abstract:Objective To observe the effects of Pyrrosia lingua (Thunb.) Farwell on immune function and allogenetic skin transplantation in mice. Methods  P. lingua of low, middle and high doses were given orally to normal mice and immunopotentiation model mice which were ip levomisole. Changes in the weight index of spleen, phagocytic activity of macrophagocyte, lymphocyte transformation, and levelsof IgM were observed. Survival of the transplanted allogenetic skin in mice which were treated with P. lingua was recorded. Result  Phagocytic activity of the macrophage, the increase of T-lymphocyte transformation and the levels of IgM in normal mice were restrained by low, middle and high dosesof P. lingua (0.05). P. lingua could regulatethe weight index of the spleen, phagocytic activity of the macrophage and the increase of T-lymphocyte transformation in immunopotentiation model mice reached normal levels. Levels of IgM in immunopotentiation model mice were significantly reduced and reached normal when given with middle doses of P. lingua. The growth time of allogenetic skin of the low dose group is 16.13 d±1.13 d, middle dose group is 15.62 d±1.01 d, and the high dose group is 14.89 d±2.01 d, which were all significantly longer than in the control group (9.75 d±0.89 d0.01). Conclusion  P. lingua could restrain immune function of normal mice, regulate the immune function of immunopotentiation model mice and help ease allograft rejection of the transplanted skin in mice.
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