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Issue:ISSN 1000-7083
          CN 51-1193/Q
Director:Sichuan Association for Science and Technology
Sponsored by:Sichuan Society of Zoologists; Chengdu Giant Panda Breeding Research Foundation; Sichuan Association of Wildlife Conservation; Sichuan University
Address:College of Life Sciences, Sichuan University, No.29, Wangjiang Road, Chengdu, Sichuan Province, 610064, China
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Your Position :Home->Past Journals Catalog->2011 Vol.30 No.2

Study on Changes in HBsAg Expression and Glutamic-pyruvic Transaminase Levels with Age in C57BL/6J-HBV Transgenic Mice
Author of the article:CHEN Di, TIAN Feng*, KANG Ai-jun, WANG Xue-wen, ZHENG Zhen-hui
Author's Workplace:(Department of Laboratory Animal Science, Health Science Center, Peking University, Beijing 100191, China)
Key Words:HBV transgenic mice; hepatitis B surface antigen; Glutamic-pyruvic transaminase
Abstract:Objective To investigate the changes in HBsAg expression and glutamic-pyruvic transaminase levels with age in C57BL/6J-HBV transgenic mice. Methods HBV transgenic mice were divided into two groups according toS/C.O value. Serum HBsAg were measured by using ELISA assay every other week from four-weeks to ten-weeks in all mice and the glutamic-pyruvic transaminase level was determined by automatic biochemical analyzer every other week from five-weeks to eleven-weeks old. Results HBsAg expression in six-week old mice went up markedly compared with four-week old individuals in the first group.HBsAg expression in six-week old male mice went down significantly (P0.01) in comparison to four-week olds in the second group while no obvious changes were observed from four-weeks to ten-weeks old in female mice of the same group. ALT levels of nine-week old male mice was lower (P<0.05) than that of seven-week olds in the first group. AST levels of eleven-week old male mice was higher than that of seven-week old mice in the first group. Conclusion The change in HBsAg expression was different because of different S/C.O values and variations in ALT and AST was reversefrom five-week to eleven-week olds in HBV transgenic mice.
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