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Issue:ISSN 1000-7083
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Your Position :Home->Past Journals Catalog->2011 Vol.30 No.2

Research Status on the Heart Failure Animal Model
Author of the article:DENG Qing-xiu, PENG Cheng*
Author's Workplace:(Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China)
Key Words: heart failure; animal model; animal disease model; combining syndrome with disease
Abstract:Heart failure is a common clinical cardiovascular syndrome. Heart failure animal models mainly include animal disease model and combining syndrome with disease. Commonly replicated methods of the animal disease models include: abdominal aorta constriction, coronary artery ligation, rapid ventricular pacing, intravenous injection of pentobarbital sodium, Adriamycin method and Isoproterenol injection. Combining syndrome with disease animal models include: acute heart failure with heart Yang deficiency syndrome, heart failure with heart Qi deficiency syndrome, heart failure with kidney Yang Deficiency syndrome, chronic heart failure with Qi deficiency and blood stasis syndrome, heart failure with heart and kidney Yang Deficiency syndrome, chronic heart failure with Yang deficiency with water retention, and heart failure with Yin deficiency with internal heat. We should select the proper heart failure animal model, including selecting the proper animal and know the principle of animal model establishment to ensure that the experimental results are scientific and reliable.
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