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Issue:ISSN 1000-7083
          CN 51-1193/Q
Director:Sichuan Association for Science and Technology
Sponsored by:Sichuan Society of Zoologists; Chengdu Giant Panda Breeding Research Foundation; Sichuan Association of Wildlife Conservation; Sichuan University
Address:College of Life Sciences, Sichuan University, No.29, Wangjiang Road, Chengdu, Sichuan Province, 610064, China
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Your Position :Home->Past Journals Catalog->2010 Vol.29 No.6

Influence of Transportation Stress on Serum Biochemical Parameters, Malondiadehyde and Total Antioxidant Capacity in Cynomolgus Monkeys
Author of the article:ZENG Xian-cheng, PAN Xue-ying, YAO Yi-shu, ZHOU Chao, JIANG Zi-rui, MA Jing*
Author's Workplace:(National Shanghai Center for Drug Safety Evaluation and Research, Shanghai Institute of Pharmaceutical Industry, Shanghai 201210, China)
Key Words:cynomolgus monkeys; transportation stress; MDA; TAOC
Abstract:Objective To evaluate the influence of long distance transportation on plasma cortisol, serum biochemical parameters, malondiadehyde (MDA) and total antioxidant capacity (TAOC) in cynomolgus monkeys (Macaca fascicularis). Methods Blood samples were collected from male cynomolgus monkeys at different time points of pre- and post-transportation and were used to determine serum biochemical parameters, MDA and TAOC. Results ALT, AST and LDH increased significantly after transportation (P<0.05). ALP, GLU and TBIL increased but there was no significant difference. BUN, CREA, TP and ALB decreased significantly after transportation (P<0.05). TCHO and CK decreased but there was no significant difference. Except for CK and LDH, all serum biochemical parameters returned to normal levels on the twenty-ninth day. Serum MDA increased gradually after transportation, reached a peak value on the second day (P<0.01) and became stable on the twenty-ninth day. Serum TAOC decreased gradually after transportation, reached the trough value on the second day (P<0.05) and became stable on the twenty-ninth day. Conclusions Transportation stress could affect the values of most of the serum biochemical parameters and cause oxidative changes in cynomolgus monkeys after transportation. At least, an adaptation period of 29 days should be guarantied for the serum biochemical parameters to return to their normal values and the oxidative versus anti-oxidative status get back to their balance.
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