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Issue:ISSN 1000-7083
          CN 51-1193/Q
Director:Sichuan Association for Science and Technology
Sponsored by:Sichuan Society of Zoologists; Chengdu Giant Panda Breeding Research Foundation; Sichuan Association of Wildlife Conservation; Sichuan University
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Your Position :Home->Past Journals Catalog->2010 Vol.29 No.4

Prion Protein Gene (PRNP) Variation and its Phylogenetic Implications for Mammals
Author of the article:GUAN Ting-long1,2, FAN Zhen-xin2, ZENG Bo2, YUE Bi-song2, ZOU Fang-dong2*
Author's Workplace:(1.Zibo Municipal Center for Disease Control and Prevention, Zibo, Shandong Province 255026, China; 2. Key Laboratory of Bio-resources and Eco-environment (Ministry of Education), College of Life Sciences, Sichuan University, Chengdu 610064, China)
Key Words: mammal; prion protein gene; stop codon; phylogeny
Abstract:Eighty-four prion protein gene (PRNP) sequences from 84 mammalian species belonging to 61 genera and 17 orders were analyzed in order to investigate its structure and differentiation among species. The lengths of PRNP coding sequences varied a lot among different species. In addition, TGA and TAG were the most widely used stop codons in mammalian PRNP, while TAA is only found in species of Perissodactyla and Marsupialia. Nucleotide diversity was high (10.54%) among all 84 sequences. The reconstructed PRNP phylogenetic tree for all 84 species matches the results of traditional studies. Our analyses suggest that PRNP could be used as a molecular marker in phylogenetic studies of high level taxonomic units. Finally, we speculate on the possibility of different orders of mammals suffering from transmissible spongiform encephalopathies according to their phylogenetic relationships.
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