Effect of Low-dose Melamine on the Quality of Spermatozoa in Mice
Author of the article:TIAN Yong-gang1, 2, ZHANG Ying-mei1*
Author's Workplace：(1. School of Life Sciences, Lanzhou University, Lanzhou 730000, China; 2. Laboratory Animal Center for Medical Science, School of Basic Medical Sciences, Lanzhou University, Lanzhou 730000, China)
Key Words：melamine; mice; parameter of sperm movement; sperm deformity
Abstract：To study the toxicity of low-dosage melamine to the seminal power of male mice, selected male mice were divided into three groups, and were treated with melamine at 1.0 mg/kg, 2.0 mg/kg, 4.0 mg/kg for 35 days through intragastric administration. The parameters of sperm movement, sperm morphology and body weight of mice were observed and analyzed after 35-day treatment. The results showed that the parameter of sperm movement obviously decreased in the group treated with 4.0 mg/kg melamine (P<0.05), whereas there was no significant change in the groups treated with 1.0 mg/kg and 2.0 mg/kg melamine. During the period from the 7th to 14th day, the body weight growth of mice treated with 2.0 mg/kg melamine decreased significantly (P<0.05), and the same happened to mice treated with 4.0 mg/kg melamine (P<0.01). Furthermore, there was no significant effect on the sperm morphology among these three groups. In conclusion, the low-dose melamine had no obvious effects on mice spermatozoa activeness and morphology.