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Issue:ISSN 1000-7083
          CN 51-1193/Q
Director:Sichuan Association for Science and Technology
Sponsored by:Sichuan Society of Zoologists; Chengdu Giant Panda Breeding Research Foundation; Sichuan Association of Wildlife Conservation; Sichuan University
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Your Position :Home->Past Journals Catalog->2010 Vol.29 No.2

Characteristics of Pathological Changes in Chronic Obstructive Pulmonary Disease (COPD) Rat Model
Author of the article:ZHANG Li, LI Jin-tian, LIU Yong-qi, LI Juan, ZHANG Yi
Author's Workplace:(Gansu College of Traditional Chinese Medcine, Lan zhou 730000, China)
Key Words:COPD; characteristics of pathological changes; experimental study
Abstract:
Objective To study the expression of pulmonary surface-active substance related protein A (Surfactant protein A, SP-A) of chronicobstructive pulmonary disease (COPD) rat model and ultrastructural changes in the lung tissue of COPD. Methods The rat model of COPD was established by both intratracheal instillation of lipopolysaccharide (LPS) and passive smoking for 28 days. Observe the general condition of rats, test the expression level of Surfactant protein A (SP-A) by immunohistochemistry, and observe the ultrastructural changes of alveolar type epithelial cells through transmission electron microscope. Results Compared with the blank group, the average numbers of SP-A-positive cells per alveolus in other groups showed significant differences (P<0.01). Conclusion It is reliable that the rat model of COPD was established by the combination of intratracheal instillation of lipopolysaccharide (LPS) and passive smoking for 28 days, and the model was still stable after ending the combination two weeks later.
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