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Issue:ISSN 1000-7083
          CN 51-1193/Q
Director:Sichuan Association for Science and Technology
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Your Position :Home->Past Journals Catalog->2010 Vol.29 No.2

Study on Self-assembled Peptides to Depressed Cell Apoptosis in Rat Experimental Acute Spinal Cord Injury
Author of the article:L? Fei, WANG Song-tao*, WANG Ting, LIU Yan-fei, ZHAO Xiao-jun*
Author's Workplace:(Institue for Nanobiomed Technology and Membrane Biology, Sichuan University, Chengdu 610065, China)
Key Words:self-assembled peptides; RADA16-1; spinal cord injury; apoptosis
Abstract:Objective To explore self-assembling peptides characteristics to apoptosis following spinal cord injury. Methods Rat model of spinal cord injury was established. Apoptosis in the injured area was examined by using terminal deoxynucleotidyl-mediated nick-end labeling (TUNEL). Results The TUNEL positive cells were detected 2 hours post injury, the number of TUNEL-positive stains reached a maximum 8 hours after injury, and there were fewer TUNEL-positive cells detected in the self-assembling peptide group (SAP group). Conclusions Self-assembly peptides do benefit to depress cell apoptosis in the spinal cord after injury.
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