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Issue:ISSN 1000-7083
          CN 51-1193/Q
Director:Sichuan Association for Science and Technology
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Your Position :Home->Past Journals Catalog->2021 Vol.40 No.5

Effects of Periplaneta americana Thymosin on Hair Growth of Mouse Model
Author of the article:YAN Lin1, GAO Jie2, ZHANG Yipeng3, WANG Hongmei1, CHEN Qin1, SHEN Yongmei2, YUE Bisong1, ZHANG Xiuyue1*
Author's Workplace:1. Key Laboratory of Bio-Resource and Eco-Environment of Ministry of Education, College of Life Sciences, Sichuan University, Chengdu 610065, China;
2. Sichuan Key Laboratory of Medicinal Periplaneta americana, Chengdu 610031, China;
3. Zhongqi Construction Engineering Co. Ltd., Chengdu 610094, China
Key Words:Periplaneta americana; thymosin; C57BL/6 mice; hair growth
Abstract:Objective To explore the effect of Periplaneta americana thymosin on hair growth and hair cycle of C57BL/6 mouse. Methods The C57BL/6 mice were divided into THY1 group, THY2 group, THY3 group and Tβ4 group with administration concentration of 500 μg·mL-1, and continuously administered for 18 days. Photographs were taken daily to record the changes in skin color and hair growth status of mice with hair removal. The effect of P. americana thymosin on hair growth of mice was determined by the changes of hair follicle morphology and quantity. The expression levels of IGF-1, β-catenin and MMP-2 in the skin were detected by real-time fluorescence quantitative PCR (qPCR) on day 6, day 12 and day 18. Results Compared with the PBS group, the skin color of mice from the administration groups changed in a shorter time after hair removal, and the number of hair follicles was significantly higher, and the hair growth was faster. Compared with the PBS group, the expression levels of β-catenin in the THY1 and THY3 groups were significantly higher on day 6, while the expression of MMP-2 in the THY2 group and the expression of IGF-1 in the THY1 group were significantly higher on day 18. Conclusion P. americana thymosin can promote the hair growth of C57BL/6 mice, and the increased expression of β-catenin, MMP-2 and IGF-1 may be one of the mechanisms by which P. americana thymosin can regulate hair follicle development and hair growth.
2021,40(5): 489-496 收稿日期:2021-01-20
分类号:Q95-33
基金项目:好医生药业集团有限公司助研项目
作者简介:颜琳,女,硕士研究生,研究方向:动物分子生物学
*通信作者:张修月,E-mail:zhangxiuyue@scu.edu.cn
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