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Issue:ISSN 1000-7083
          CN 51-1193/Q
Director:Sichuan Association for Science and Technology
Sponsored by:Sichuan Society of Zoologists; Chengdu Giant Panda Breeding Research Foundation; Sichuan Association of Wildlife Conservation; Sichuan University
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Your Position :Home->Past Journals Catalog->2008 Vol.27 No.6

Changes of PPARβ mRNA Expression Induced by Global Cerebral Ischemia/Reperfusion Injury in Rat Hippocampi
Author of the article:ZHUANG Rui-chun, YANG Jun-qing, XIAO Xiao-hua, PAN Yong-quan, ZHANG Yun-mei
Author's Workplace:(Department of Pharmacology, Chongqing Key Laboratory of Biochemistry and Molecular Pharmacology, Chongqing Medical University, Chongqing 400016, China)
Key Words:PPARβ mRNA expression; global cerebral ischemia/reperfusion; brain injury
Abstract: Objective To investigate the changes of PPARβ mRNA expression induced by global cerebral ischemia/reperfusion injury in rat hippocampi. Methods The model of global cerebral ischemia/reperfusion injury was established by bilateral common carotid arteries occlusion and haemospasia hypotension in rats. Spatial learning and memory function of rat was determined by Morris water maze. Morphologic changes of hippocampal neurons were evaluated by HE staining. The PPARβ mRNA expression in hippocampi was detected by RT-PCR. Results The spatial learning and memory function of global cerebral ischemia/reperfusion injury rat was significantly impaired compared with that of sham operated group. Hippocampal neurons in model rat showed obviously karyopycnosis. The PPARβ mRNA expression in hippocampi increased remarkably at 2 h after global cerebral ischemia/reperfusion compared with that of sham operated group, and reached the peak at 48 h. At 15 d the level of PPARβ mRNA expression was still higher than that of sham operated group. But there was no significance the levels of PPARβ mRNA between model group and sham operated group at 30 d. Conclusion Global cerebral ischemia/reperfusion can induce the increase of PPARβ mRNA expression in rat hippocampi, and it may protect the brain function against global cerebral ischemia/reperfusion injury.
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