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Issue:ISSN 1000-7083
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Your Position :Home->Past Journals Catalog->2008 Vol.27 No.5

Expression Level of Telomerase Reverse Transcriptase in Development of Rat Hepatocellular Carcinoma
Author of the article:CHEN Ying
Author's Workplace:(School of Life Sciences and Technology, Henan Institute of Science and Technology, Xinxiang, Henan Province 453003, China)
Key Words: telomerase reverse transcriptase; hepatocellular carcinoma; rat
Abstract:Telomerase reverse transcriptase (TERT) expression, which is closely associated with cell immortalization and carcinogenesis,  is regarded as a rate-limiting factor in the regulation of telomerase activity. The expression of TERT was detected using Western blot and immunofluorescence analysis, respectively, in rat hepatocellular carcinoma (HCC) model induced by diethyl nitrosoamine (DENA). The low expression level of TERT was detected and maintained at a relative stable level in normal tissue and normal tissue adjacent to tumor, whereas the expression of TERT was significantly increased in hepatocirrhosis stage, especially in HCC stage. Therefore, over-expression of TERT was consistent with the progression of HCC.
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