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Issue:ISSN 1000-7083
          CN 51-1193/Q
Director:Sichuan Association for Science and Technology
Sponsored by:Sichuan Society of Zoologists; Chengdu Giant Panda Breeding Research Foundation; Sichuan Association of Wildlife Conservation; Sichuan University
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Your Position :Home->Past Journals Catalog->2017 Vol.36 No.6

Effects of Swimming Exercise on Learning and Memory Ability of APP/PS1 Transgenic Mice
Author of the article:FAN Zongshan1,2, JING Guangwei3, ZHAO Haipeng4*
Author's Workplace:1. Henan Vocational College of Agriculture, Zhongmou, Henan Province 451450, China;
2. Physical Education Institute of Henan Normal University, Xinxiang, Henan Province 453002, China;
3. Henan Jigong Mountain National Nature Reserve Management Bureau, Xinyang, Henan Province 464000, China;
4. School of Life Science, Henan University, Kaifeng, Henan Province 475001, China
Key Words:APP/PS1 transgenic mice; swimming; learning and memory
Abstract:To investigate the effects of swimming on learning and memory ability of APP/PS1 transgenic mice. 11-month-old male APP/PS1 transgenic mice were randomly divided into control group and swimming group. The control group had no exercise, and the swimming group had swimming training for 1 month. The expression of Aβ plaques, neuron apoptosis, mitochondria biogenesis-related protein expression and the learning and memory of APP/PS1 transgenic mice were determined by Congo red staining, Tunel assay, Western Blot and Morris water maze. The result showed that swimming exercise reduced the formation of Aβ plaques and neuronal apoptosis, promoted mitochondria biogenesis in the cerebral cortex of APP/PS1 transgenic mice, and enhanced the ability of learning and memory of APP/PS1 transgenic mice. This study suggested that swimming can promote the learning and memory ability of APP/PS1 transgenic mice by facilitating mitochondria biogenesis, and thus can be used as a treatment for the prevention and treatment of Alzheimer's disease.
2017,36(6): 663-668 收稿日期:2017-08-11
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