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Issue:ISSN 1000-7083
          CN 51-1193/Q
Director:Sichuan Association for Science and Technology
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Your Position :Home->Past Journals Catalog->2017 Vol.36 No.5

Protective Effects of Olive Leaf Extract on Alcohol Hepatic in Rats
Author of the article:WANG Yu
Author's Workplace:Center for Research & Development of Longnan Characteristic Agro-bioresources, College of Agriculture and Forestry, Longnan Teachers College, Chengxian, Gansu Province 742500, China
Key Words:olive leaf extract; alcohol; inflammatory factors; SREBP-1c; antioxidant capacity
Abstract:Objective Explore the protective role of olive leaf extract (OLE) on alcohol hepatic injury. Methods A hepatic injury model of rat was established by using edible alcohol with increasing dosages for 24 weeks.And then the rats were given OLE at the doses of 250 mg·kg-1,500 mg·kg-1 or 1 000 mg·kg-1 by intragastric administration.The changes of liver histological structure were observed by bio-microscopy.The levels of alanine aminotransferase (ALT),aspartate aminotransferase (AST),triglyceride (TG),and total cholesterol (TC) in serum were tested.The contents of tumor necrosis factor-α(TNF-α) and interleukin-1β(IL-1β) were detected by radioimmunoassay and the activities of superoxide dismutase (SOD),catalase (CAT),glutathione reductase (GR) and malondialdehyde (MDA) content in liver were determined by spectrophotometry,and the expression of sterol regulatory element-binding protein 1c (SREBP-1c) in liver were analyzed by immunohistochemistry. Results Compared with the model group,the treatments of OLE could significantly decrease the levels of TG,TC,ALT,AST,TNF-α,IL-1β,MDA and SREBP-1c expression,while the activities of SOD,CAT and GR were significantly increased.Furthermore,the liver injury was alleviated along with the treatment of OLE. Conclusion OLE has a protective effect on alcohol hepatic injury,and this may be due to the reduced free radical lesion,relieved inflammatory response and inhibited SREBP-1c expression.
2017,36(5): 557-562 收稿日期:2017-02-07
DOI:10.11984/j.issn.1000-7083.20170034
分类号:Q959.8;Q55
基金项目:甘肃省高等学校科研资助项目(1128B-01);甘肃省陇南市科技计划项目(2016-11)
作者简介:王昱(1973-),男,硕士,教授,研究方向:天然产物药理、细胞与发育生物学,E-mail:gswangyu@126.com
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