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Issue:ISSN 1000-7083
          CN 51-1193/Q
Director:Sichuan Association for Science and Technology
Sponsored by:Sichuan Society of Zoologists; Chengdu Giant Panda Breeding Research Foundation; Sichuan Association of Wildlife Conservation; Sichuan University
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Your Position :Home->Past Journals Catalog->2017 Vol.36 No.2

Effect of Oxytocin in the Medial Amygdala on the Social Behavior of Lasiopodomys brandtii
Author of the article:ZHANG Nan, YAN Lixin, GAO Jie, SUN Xiuping, SONG Mingjing*
Author's Workplace:Key Laboratory of Human Diseases Comparative Medicine, Ministry of Health, Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences & Comparative Medicine Center, Peking Union Medical College, Beijing 100021, China
Key Words:Lasiopodomys brandtii; oxytocin; medial amygdala; social memory; prosocial
Abstract:Objective To explore the influence of oxytocin (OT) in the medial amygdala (MeA) on the social behaviors of Brandt's voles (Lasiopodomys brandtii). Methods Oxytocin receptor antagonist (OTRA) was injected into the MeA of male Brants's voles, and then the social behaviors were tested using social recognition experiment and neutral arena encounter experiment. Results The control group (injected with artificial cerebrospinal fluid) took more time to explore the strangers than the familiars (0.001 < P < 0.01). However, the experimental group took the similar time to investigate the strangers and the familiars (P>0.05). And the experimental group spent significantly less time on empty cage, stimulus and strangers than that of the control group (0.01 < P < 0.05). The experimental group showed similar attack time and incubation time of attack than the control (P>0.05). Conclusion OT in MeA can influence the social recognition and memory ability of the Brandt's voles, but cannot affect its attack behavior. Therefore, it was concluded that the expression of OT in MeA could affect Brandt's voles' social behavior by impairing the ability of social memory, rather than changing their prosocial ability.
2017,36(2): 193-197 收稿日期:2016-10-21
基金项目:国家自然科学基金项目(31301890);农业虫害鼠害综合治理研究国家重点实验室开放研究基金项目(Chinese IPM1615)
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