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Your Position :Home->Past Journals Catalog->2017 Vol.36 No.1

Progresses of Research on the Function of LncRNA Involved in Mammalian Spermatogenesis
Author of the article:WU Shixin, XU Chuanfei, SUN Lei, ZHAO Wangsheng, CAI Xin*
Author's Workplace:College of Life Science and Engineering, Southwest University of Science and Technology, Mianyang, Sichuan Province 621010, China
Key Words:lncRNA; origin; mechanism; mammal; spermatogenesis
Abstract:Long non-coding RNA (lncRNA) is the functional RNA segment longer than 200 nucleotides, locating in the nucleus or the cytoplasm, with little or no protein-coding capacity. LncRNAs can regulate gene expression at epigenetic, transcription and post-transcription level. Spermatogenesis is a well-orchestrated biological process, which is composed of meiotic division of spermatocytes and post-meiotic differentiation of haploid spermatids into mature spermatozoa. This process is strictly modulated by phase-specific gene expression under the regulation of plenty of lncRNAs. Although lncRNAs widely participate in various physiological and pathological processes as a new class of important regulatory factors, yet little information is available in the process of spermatogenesis. The identification of spermatogenesis-related lncRNAs and their biological function research are still remaining unknown. Therefore, this article summarized the recent research progresses on the origin and function mechanism of lncRNAs as well as their regulatory roles in spermatogenesis.
2017,36(1): 114-120 收稿日期:2016-06-22
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