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Issue:ISSN 1000-7083
          CN 51-1193/Q
Director:Sichuan Association for Science and Technology
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Your Position :Home->Past Journals Catalog->2017 Vol.36 No.1

Effects of Early Social Isolation on Anxiety Levels, Social Behaviors, and Neuroendocrine in Female ICR Mice
Author of the article:CHENG Guangchao, XIE Limeng, WANG Jianli*
Author's Workplace:College of Biological Sciences and Engineering, Beifang University of Nationalities, Yinchuan 750021, China
Key Words:isolation; stress; anxiety; hippocampus; female
Abstract:Accumulating evidence showed that early life stress induces significant behavioral and neurochemical changes in adulthood. However, the mechanisms of this process are not well understood. Brain-derived neurotrophic factor (BDNF), oxytocin (OT) and glucocorticoid receptor (GR) are implicated in the neuroadaptational response to stress. In this study, female ICR mice pups were subjected to repeated separation 3 h per day from postnatal day (PND) 3 to PND 21. On PND 60, the anxiety levels, social behaviors, serum corticosterone (CORT) and OT were assessed, while the expression of BDNF-, OT- and GR-immunoreactive (ir) neurons were also examined. The results showed that early social isolation enhanced anxiety levels and resulted in a reduction in locomotion and social behaviors compared to the control. Along with these changes, isolation treatment significantly up-regulated the levels of CORT in serum, and decreased the BDNF-ir and GR-ir expression in the CA1 and CA2/3 of the hippocampus, as well as OT-ir expression in the paraventricular nucleus and supraoptic nucleus. These findings demonstrated that early social isolation down-regulated the levels of BDNF, OT and GR, which were involved in mediating the stress system to affect emotion and social behaviors.
2017,36(1): 39-47 收稿日期:2016-09-05
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