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Issue:ISSN 1000-7083
          CN 51-1193/Q
Director:Sichuan Association for Science and Technology
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Your Position :Home->Past Journals Catalog->2016 Vol.35 No.6

The Spatial Learning and Memory Function were Reduced in Chronic Fatigue Syndrome Mice
Author of the article:ZHAO Hai, YAO Gang, QIAN Ning, CHEN Mingfei, YANG Zhi, WU Shuguang*
Author's Workplace:Institute of Laboratory Animals, Guiyang College of Traditional Chinese Medicine, Guiyang 550002, China
Key Words:Morris water maze; compound stimulus; cognitive function; spatial learning and memory
Abstract:Objective To analysis the differences of spatial learning and memory function between chronic fatigue syndrome and normal mice. Methods The chronic fatigue syndrome (CFS) mice was first established by compound stimulus method, and then the differences of spatial learning and memory function between chronic fatigue syndrome and normal mice were explored using Morris water maze test. Results The time of latency, path length, average swim speed and percent time in target quadrant for searching hidden platform were significantly decreased in CFS mice compared with the normal group (P<0.05). The normal mice adopt spatial strategy to find the hidden platform, while the CFS mice will adopt a repetitive looping strategy. Conclusion The spatial learning and memory function was decreased in CFS mice compared with the normal mice.
2016,35(6): 879-883 收稿日期:2016-06-14
DOI:10.11984/j.issn.1000-7083.20160161
分类号:Q959.837
基金项目:贵阳中医学院院内项目([2015]01)
作者简介:赵海,硕士,助理实验师,从事胎盘形成研究,E-mail:344947218@qq.com
*通讯作者:吴曙光,硕士,高级实验师,从事中医药实验动物学研究,E-mail:243099502@qq.com
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