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Your Position :Home->Past Journals Catalog->2016 Vol.35 No.4

Effects of Cocaine on Locomotion, Social Behaviors and the Expression of Central Arginine Vasopressin, Oxytocin and Tyrosine Hydroxylase in Female Mandarin Voles
Author of the article:HE Chen, WANG Jianli*, CHENG Guangchao
Author's Workplace:College of Biological Sciences and Engineering, Beifang University of Nationalities, Yinchuan 750021, China
Key Words:cocaine; anxiety; aggressive behavior; neuropeptide; dopamine
Abstract:Arginine vasopressin (AVP) and oxytocin (OT) are associated with the regulation of social behaviors and involved in drug abuse by mediating dopamine (DA) activity. Mandarin voles (Lasiopodomys mandarinus) are socially monogamous rodents with complex social behaviors. Tyrosine hydroxylase (TH) is an indicator of DA production. In this study, female mandarin voles were treated by cocaine [20 mg·(kg·d)-1] for 4 days, and the locomotion, anxiety levels and social behaviors as well as the expression of AVP, OT and TH-immunoreactive (IR) neurons were then assessed after 24 h of withdrawal. Compared to the saline control, cocaine-treated group exhibited higher levels of locomotion and less social behaviors and aggressive behavior. However, anxiety levels were not altered. In addition, we found that cocaine resulted in a reduction of AVP-IR neurons in the anterior hypothalamus and OT-IR neurons in the paraventricular nucleus (PVN). Furthermore, more TH-IR neurons in the PVN and VTA were found in the cocaine-treated group. Taken together, these results suggested that repeated cocaine exposure may alter behavioral sensitization and social behaviors in female mandarin voles, and AVP, OT and DA may play potential regulatory roles.
2016,35(4): 488-495 收稿日期:2016-04-16
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