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Issue:ISSN 1000-7083
          CN 51-1193/Q
Director:Sichuan Association for Science and Technology
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Your Position :Home->Past Journals Catalog->2015 Vol.34 No.3

Effects of Modeling Time on Rat Depression Model Induced by Chronic Unpredicted Mild Stress
Author of the article:YANG Chanjuan1, AN Ruidi2, YANG Junqing2, LUO Ying2, QI Yun3, ZHANG Yunmei1*
Author's Workplace:1. Nursing School, Chongqing Medical University, Chongqing 400016, China;
2. Pharmacy School, Chongqing Medical University, Chongqing 400016, China;
3. Southwest Pharmaceutical Co., Ltd., Chongqing 400038, China
Key Words:depression; modeling time; success rate; chronic unpredicted mild stress
Abstract:Objective To investigate the effects of modeling time on success rate of rat depression model induced by chronic unpredicted mild stress. Methods A total of 240 experimental rats were randomly divided randomly into 4 groups (60 per group), and were given chronic unpredicted mild stress for 21 d, 35 d, 49 d and 63 d, separately. The behaviors of rats were evaluated by open-field test, sucrose preference test, high plus maze test, forced swimming test and so on. Methods The ratios of open arm entry, open arm time and the ratios of open arm time were significantly deceased in successful group, compared with those in control, while the consumption of sucrose were significantly decreased, and the open-field latency were increased significantly. Conclusion The success rate of depression model increased with the modeling time, which suggested that prolonging modeling time may increase the success rate of modeling, therefore, 49 d was the best modeling time.
2015,34(3): 383-388 收稿日期:2014-10-29
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