Latest Cover

Online Office

Contact Us

Issue:ISSN 1000-7083
          CN 51-1193/Q
Director:Sichuan Association for Science and Technology
Sponsored by:Sichuan Society of Zoologists; Chengdu Giant Panda Breeding Research Foundation; Sichuan Association of Wildlife Conservation; Sichuan University
Address:College of Life Sciences, Sichuan University, No.29, Wangjiang Road, Chengdu, Sichuan Province, 610064, China
Tel:+86-28-85410485
Fax:+86-28-85410485
Email:scdwzz@vip.163.com & scdwzz001@163.com
Your Position :Home->Past Journals Catalog->2015 Vol.34 No.3

Effects of Modeling Time on Rat Depression Model Induced by Chronic Unpredicted Mild Stress
Author of the article:YANG Chanjuan1, AN Ruidi2, YANG Junqing2, LUO Ying2, QI Yun3, ZHANG Yunmei1*
Author's Workplace:1. Nursing School, Chongqing Medical University, Chongqing 400016, China;
2. Pharmacy School, Chongqing Medical University, Chongqing 400016, China;
3. Southwest Pharmaceutical Co., Ltd., Chongqing 400038, China
Key Words:depression; modeling time; success rate; chronic unpredicted mild stress
Abstract:Objective To investigate the effects of modeling time on success rate of rat depression model induced by chronic unpredicted mild stress. Methods A total of 240 experimental rats were randomly divided randomly into 4 groups (60 per group), and were given chronic unpredicted mild stress for 21 d, 35 d, 49 d and 63 d, separately. The behaviors of rats were evaluated by open-field test, sucrose preference test, high plus maze test, forced swimming test and so on. Methods The ratios of open arm entry, open arm time and the ratios of open arm time were significantly deceased in successful group, compared with those in control, while the consumption of sucrose were significantly decreased, and the open-field latency were increased significantly. Conclusion The success rate of depression model increased with the modeling time, which suggested that prolonging modeling time may increase the success rate of modeling, therefore, 49 d was the best modeling time.
2015,34(3): 383-388 收稿日期:2014-10-29
DOI:10.3969/j.issn.1000-7083.2015.03.010
分类号:Q95-33
基金项目:重庆科委项目cstc2012jjA0112;重庆科委项目cstc2011AC5203
作者简介:杨婵娟(1989—),女,硕士研究生,研究方向:护理学,E-mail:273152390@qq.com
*通讯作者:张云美,副教授,E-mail:cyzym@126.com
参考文献:
陈红霞, 张黎明, 薛摇瑞, 等. 2011. 大鼠嗅球切除抑郁症动物模型的改进与评价[J]. 中国药理学通报, 27(3): 436-439.
董海影, 兴桂华, 张晓杰. 2011. 不同年龄组大鼠抑郁症模型评价[J]. 中国老年学杂志, 31(10): 1796-1797.
李宁, 唐启盛, 赵瑞珍, 等. 2010. 慢性焦虑应激大鼠行为学的变化及高架十字迷宫的测评[J]. 中华中医药学刊, 28(4): 711-712.
李晓秋, 许晶. 2002. 抑郁动物模型的研究进展[J]. 中华精神科杂志, 35(3): 184-186.
马妮, 陈林庆, 蔺兴遥, 等. 2010. 慢性应激抑郁症大鼠模型的复制与评价[J]. 甘肃中医学院学报, 27(8): 7-8.
汤球, 刘志学, 崔淑芳, 等. 2011. 大鼠抑郁症模型的建立与评价[J]. 实验动物科学杂志, 28(1): 6-9.
王海涛, 薛黎明, 秦雪梅, 等. 2010. 慢性不可预知和慢性束缚应激抑郁模型大鼠行为学研究[J]. 山西大学学报: 自然科学版, 33(1): 157-160.
王建醒, 周丽, 徐华锋. 2006. 慢性应激大鼠抑郁模型的建立及其评价[J]. 齐齐哈尔医学院学报, 27(6): 644-646.
王亚军, 张瑜, 田永萍. 2008. 针药结合治疗对慢性应激抑郁模型大鼠行为学的影响[J]. 中医研究, 21(11): 12-15.
夏军, 叶慧, 周义成. 2005. 慢性应激大鼠抑郁模型的建立及其有效性的探讨[J]. 华中科技大学学报: 医学版, 34(4): 493-495.
宗绍波, 魏盛, 苏云祥. 2011. 焦虑大鼠模型高架十字迷宫实验的复测信度检验及参数相关性分析[J]. 中国医药导报, 8(30): 5-7.
Benelli A, Filaferro M, Bertolini A, et al. 1999. Influence of S-adenosyll-methionine on chronic mild stress-induced anhedonia in cast rated rats[J]. British Journal of Pharmacology, 127: 645-654.
Foreman MM, Hanania T, Eller M. 2009. Anxiolytic effects of lamotrigine and JZP-4 in the elevated plus maze and in the four plate conflict test[J]. Eur J Pharmacol, 602(2-3): 316-320.
Porsolt RD, Bertin A, Jalfre M. 1977. Behavioural despair in mice: a primary screening test for antidepressants[J]. Arch Int Pharmacodyn, 229(21): 327-336.
Rasenick MM, Chaney KA, Chen JG. 1996. Protein-mediated signal transduction as atarget of antidepressant and an tibipolar drug action: Evidence from model systems[J]. J Clin Psychiatry, 57(suppl 13): 49-55.
Washington DC. 1994. American Psychiatric Association. DSM - Ⅲ Diagnostic and statistical manual of psychiatric disorders, 4th ed[M]. American Psychiatric Association.
Willner P. 1986. Validation criteria for animal models of human mental disorders: learned helplessness as a paradigm case[J]. Prog Neuropsy chopharmalol Biol Psychiatry, 10(6): 677-690.
Zhao Z, Wang W, Guo H, et al. 2008. Antidepressant-like effect of liquiritin from Glycyrrhiza uralensis in chronic variable stress induced depression model rats[J]. Behavior Brain Res, 194(1): 108-113.
CopyRight©2020 Editorial Office of Sichuan Journal of Zoology