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Issue:ISSN 1000-7083
          CN 51-1193/Q
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Your Position :Home->Past Journals Catalog->2014 Vol.33 No.4

Study on the Anti-fertility Effect of Sophoricoside on Female Mice
Author of the article:QU Chengquan, SUN Qi, ZHOU Jianhong, YANG Zhirong, ZHANG Jie*
Author's Workplace:(College of Life Science, Sichuan University, Chengdu 610064, China)
Key Words:sophoricoside; anti-fertility; endometrial receptivity; estrogen receptor; progesterone receptor
Abstract:Mice of the ICR strain were orally administered with Sophoricoside (SOPH) to investigate the anti-fertility effect on female mice. The pregnant mice received SOPH at concentrations of 0 mg/kg·day, 150 mg/kg·day, 300 mg/kg·day and 600 mg/kg·day from day 1 (D1) of gestation to sacrifice, and the effects of the treatment on fertility were evaluated. Administration of SOPH led to blocked formation of pinopodes, compromised endometrial receptivity (D5) and decreased number of embryo implantation sites (P<0.01). The protein expression (D4, D5 and D6) level of ERα was down-regulated (P<0.05) by SOPH in the mouse endometrium, while the PR was up-regulated (P<0.01). This study suggested that sophoricoside can cause the failure of embryo implantation by modulating the expression levels of ERα and PR in uterus, affecting the formation of pinopodes and reducing mice endometrial receptivity.
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