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Issue:ISSN 1000-7083
          CN 51-1193/Q
Director:Sichuan Association for Science and Technology
Sponsored by:Sichuan Society of Zoologists; Chengdu Giant Panda Breeding Research Foundation; Sichuan Association of Wildlife Conservation; Sichuan University
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Your Position :Home->Past Journals Catalog->2014 Vol.33 No.4

Effect of Arecoline on the ERα and PR of Pregnant Mice Uterus
Author of the article:ZHOU Jianhong1, WANG Zongyong2, ZHANG Maoyu1, LIU Yanglu1, ZHANG Jie1*, YANG Zhirong1
Author's Workplace:(1. College of Life Sciences, Sichuan University, Chengdu 610064, China; 2. Forest Pest Control and Quarantine Station of Forestry Bureau in Xiangxi Autonomous State, Xiangxi, Hunan Province 416000, China)
Key Words:arecoline; embryo implantation; uterine morphology; ERα; PR
Abstract:ICR pregnant mice were used to explore the antifertility effects of arecoline and its influence on the ERα and PR. The pregnant mice were intraperitoneally injected with 0 mg/kg·day, 5 mg/kg·day, 10 mg/kg·day and 20 mg/kg·day arecoline. The statistical results showed that arecoline decreased the number of embryo implantation and uterine weight in a dose-dependent manner. When the dose was 20 mg/kg·day, the number of embryo implantation was decreased to 59% and the uterine weight was decreased to 77% in arecoline-treated group, in compared to the control. The result of HE staining indicated that the 20 mg/kg·day arecoline treated mice showed an opened endometrial lumen on D5 and failed in decidualization on D6. Additionally, the results of real-time PCR and immunohistochemistry demonstrated that the both mRNA and protein of ERα and PR in uterus were significantly up-regulated during the implanting period (P<0.05).
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