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Issue:ISSN 1000-7083
          CN 51-1193/Q
Director:Sichuan Association for Science and Technology
Sponsored by:Sichuan Society of Zoologists; Chengdu Giant Panda Breeding Research Foundation; Sichuan Association of Wildlife Conservation; Sichuan University
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Your Position :Home->Past Journals Catalog->2014 Vol.33 No.1

Comparison of Two Kinds of Type 1 Diabetic Rabbit Models Induced by Alloxan or Streptozotocin
Author of the article:GUO Zhongjie, PENG Juan, LUO Tianyou*, LIU Xiaohu
Author's Workplace:(Department of Radiology, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China)
Key Words:alloxan; streptozocin; type 1 diabetes mellitus; rabbits
Abstract:Objective To develop an optimal type 1 diabetic animal model by evaluating and comparing two kinds of type 1 diabetic rabbit models induced by alloxan (ALX) and streptozotocin (STZ), respectively. Methods Seventy rabbits were randomized into two treatment groups (28 rabbits per group) and one control group (14 rabbits). One treatment group was administered with two doses of ALX at the concentration of 100 mg/kg and 120 mg/kg at an interval of 48 h, and the other treatment group was administered with STZ in the same way. The control group was administered with equivalent amount of physiological saline. The fasting blood glucose, urine glucose, urine ketones, body weight, daily water intake, urinary output, osmolality, and electrolytes of all the groups were monitored at different time points after drug administration. Results The incidences of ALX- and STZ- induced diabetes were 71.43% and 64.26%, and the mortalities were 25% and 17.86%, respectively. However, no significant difference was observed in the incidence or mortality between the two treated groups. Conclusion Both ALX and STZ can be used to establish type 1 diabetic rabbit models, and ALX-induced diabetic model is the first option because of equivalent incidence of diabetes development and lower mortality, as well as lower cost than STZ-induced diabetic model.
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