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Issue:ISSN 1000-7083
          CN 51-1193/Q
Director:Sichuan Association for Science and Technology
Sponsored by:Sichuan Society of Zoologists; Chengdu Giant Panda Breeding Research Foundation; Sichuan Association of Wildlife Conservation; Sichuan University
Address:College of Life Sciences, Sichuan University, No.29, Wangjiang Road, Chengdu, Sichuan Province, 610064, China
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Your Position :Home->Past Journals Catalog->2013 Vol.32 No.6

The Expression and Role of Aquaporins in Lung Tissue of Yarkand Hares
Author of the article:ZHANG Jianping, LI Shuwei, CHEN Jie
Author's Workplace:(College of Life Science, Tarim University, Xinjiang Production & Construction Corps Key Laboratory of Protection and Utilization of Biological Resources in Tarim Basin, Alar, Xinjiang Uygur Autonomous Region 843300, China)
Key Words:Lepus yarcandensis; aquaporins; lung; immunohistochemistry

We detected the expression of aquaporin (AQP) 1, AQP3 and AQP4 in lung of yarkand hares (Lepus yarcandensis) to investigate the role of AQP in animal water metabolism in arid area. The histological structure of lungs was observed by using HE staining, and the expression of AQP1, AQP3 and AQP4 were detected by using the method of immunohistochemistry. The results showed that AQP1 was localized in bronchioles, blood vessels and pulmonary alveoluses; AQP3 was localized in apical membrane and basal membrane of epithelial cells in bronchioles; AQP4 was observed at the epithelial cells basal membrane of bronchioles. The expression levels of AQP1, AQP3 and AQP4 in lung were AQP1>AQP4>AQP3. These results suggested that AQP may play a key role in water transport of alveolar cavity, pulmonary interstitial and capillary cavity in yarkand hares. Furthermore, this protein is important to air wetness and reabsorption of water.

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