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Issue:ISSN 1000-7083
          CN 51-1193/Q
Director:Sichuan Association for Science and Technology
Sponsored by:Sichuan Society of Zoologists; Chengdu Giant Panda Breeding Research Foundation; Sichuan Association of Wildlife Conservation; Sichuan University
Address:College of Life Sciences, Sichuan University, No.29, Wangjiang Road, Chengdu, Sichuan Province, 610064, China
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Your Position :Home->Past Journals Catalog->2013 Vol.32 No.5

Evolution of Primates TRIM5 Gene and Anti-retrovirus Diversity
Author of the article:ZHAO Guang1, REN Rui1, WANG Hongxing2, YUE Bisong1, LI Jing1*, YI Yong2*
Author's Workplace:(1. Sichuan Key Laboratory of Conservation Biology on Endangered Wildlife, College of Life Science, Sichuan University, Chengdu 610064, China; 2. Experimental Animal Institute of Sichuan Academy of Medical Sciences & Sichuan Provincial People’s Hospital, Chengdu 610212, China)
Key Words:TRIM5; TRIMCyp; evolution; anti-retrovirus effect

Primates TRIM5 gene encodes an inhibition factor named TRIM5α which can inhibit the replication of HIV-1 at initial infection. In addition to TRIM5, another fusion gene named TRIMCyp has been found in primate genome. Due to the different splicing mechanism, TRIMCyp gene can encode different products with different anti-retrovirus activities in new world monkeys and old world monkeys. TRIM5 gene evolved several mutations during primate evolution and causing diverse anti-retrovirus abilities of different primates. The current paper reviewed the evolution of TRIM5 gene in different primate lineages by discussing the structure of TRIM5 and spliced proteins. The genetic variations of TRIM5 induced anti-retrovirus diversity in different primates were also discussed and providing an insight into the evolution of primates and TRIM5 gene.

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