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Issue:ISSN 1000-7083
          CN 51-1193/Q
Director:Sichuan Association for Science and Technology
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Your Position :Home->Past Journals Catalog->2013 Vol.32 No.4

Comparative Study of HFJ Rats with Wistar Rats on the Animal Models for Atherosclerosis Disease
Author of the article:LIAN Weiguang, ZHENG Long, YOU Hongyu, LIU Jianmin, ZHANG Dongming, LIU Fuying, WANG Junxia*
Author's Workplace:(Hebei Medical University, Hebei Key Lab of Laboratory Animal Science, Shijiazhuang 050017, China)
Key Words:atherosclerosis; animal model; immune injury; HFJ rats
Abstract:Objective To establish and compare atherosclerosis models of Wistar closed colony rats and high fecundity inbred HFJ rats by feeding high-fat diets and immune injury. Methods Male Wistar rats and HFJ inbred rats were randomly divided into normal group and model group. The normal group was fed with basic diet. The model group was fed a high-fat diet and received immune injury (bovine serum albumin 40 mg/kg, chicken egg albumin 2.5 mg/kg) and gastric perfusion of vitamin D3. The serum lipid level, biochemical indices and pathological changes were examined after 90 days. The expression of vascular endothelial growth factor (VEGF) in the aortic arch was detected by immunehistochemical techniques. Results (1) In normal group, the values of TG, TC and LDL-C in HFJ inbred rats were significantly higher than in Wistar rats (P<0.05).. The production of LDL-C in model group of HFJ rats also showed a higher level than in Wistar rats (P<0.05); (2) The content of CK and CK-Mb in model groups were statistically higher than those of normal animals (P<0.05); (3) After HE staining, typical pathologic stage characters of atheromatous plaques was observed in the model group of HFJ inbred rats rather than in Wistar rats; (4) The expression of VEGF in the model group HFJ inbred rats was higher than in Wistar rats as determined by immunehistochemical techniques (P<0.05). Conclusion An atherosclerosis mouse model was successfully developed based on HFJ inbred rats, which could provided a new strain of laboratory animal for AS researches.
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