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Issue:ISSN 1000-7083
          CN 51-1193/Q
Director:Sichuan Association for Science and Technology
Sponsored by:Sichuan Society of Zoologists; Chengdu Giant Panda Breeding Research Foundation; Sichuan Association of Wildlife Conservation; Sichuan University
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Effect of Periplaneta americana on blood sugar and creatinine in mice
Author of the article:GAO Jie, LIU Jinhua,SUN Xiaohong, LIU Shiyao
Author's Workplace:College of Life Sciences, Sichuan University
Key Words:Periplaneta americana, High-fat diet, Blood glucose, Creatinine
Abstract:Objective To investigate the effects of Periplaneta americana on body weight, blood glucose and creatinine in mice with high-fat diet. Methods The mice fed with high-fat diet were divided into control group and experimental groups (Periplaneta americana low dose group 100 mg/kg, medium dose group 200 mg/kg and high dose group 400 mg/kg), and the body weight changes were observed. On the 42th and 49th day, serum samples were taken and the fasting blood glucose and creatinine levels were measured by kits, the mRNA expression levels of glucose-6-phosphatase (G-6-Pase) and glucose transporter 2 (GLUT2 or SLC2A2) in liver tissues and monocyte chemoattractant protein -1 (MCP-1) in kidney tissues were detected by Real-time PCR. Results The weight growth rates of middle and high dose groups declined significantly on the 42th and 49th day compared to the control group (P<0.05, P<0.01). On the 42th day, compared with the control group, the blood glucose, creatinine and MCP-1 mRNA levels in mice of experimental groups showed the decreasing trend (P>0.05); G-6-Pase mRNA levels in the middle and high dose groups were dramatically lower (P <0.01); GLUT2 mRNA levels did not change notably (P> 0.05). On the 49th day, the blood glucose and creatinine levels in the low and high dose groups were significantly lower than control group (P<0.05) ; Compared with the control group, G-6-Pase, GLUT2 and MCP-1 mRNA levels in the low, medium and high dose groups were remarkably decreased (P<0.05, P<0.01). Conclusion Periplaneta americana can reduce the weight growth rate, blood glucose and creatinine levels in mice induced by high-fat diet; Decreasing the expression of G-6-Pase mRNA and regulating the expression of GLUT2 mRNA in liver may be one of the hypoglycemic mechanisms of Periplaneta americana, and it may reduce the renal injury by declining the expression of MCP-1 mRNA in kidney.
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