Latest Cover

Online Office

Contact Us

Issue:ISSN 1000-7083
          CN 51-1193/Q
Director:Sichuan Association for Science and Technology
Sponsored by:Sichuan Society of Zoologists; Chengdu Giant Panda Breeding Research Foundation; Sichuan Association of Wildlife Conservation; Sichuan University
Address:College of Life Sciences, Sichuan University, No.29, Wangjiang Road, Chengdu, Sichuan Province, 610064, China
Fax:+86-28-85410485 &
Your Position :Home->Past Journals Catalog->预发布卷

Single Nucleotide Polymorphisms of the Partial Sequence of SLA-DRB Gene in Pujiang Population of Tibetan Pigs and Correlation with Growth Traits
Author of the article:ZHU W, ZHU L, HE F, FU L, SHUAI S, Jiang J
Author's Workplace:Chengdu Institute of Biology,Chinese Academy of Sciences Sichuan zhongce Environmental Technology Co., Ltd College of Animal Science,Sichuan Agricultural University Chengdu Institute of Biology,Chinese Academy of Sciences College of Animal Science,Sichuan Agricultural University Chengdu Institute of Biology,Chinese Academy of Sciences
Key Words:SLA-DRB; cannon bone circumference; immunity; genetic breeding; Tibetan pig
Abstract:The single nucleotide polymorphism of swine leukocyte antigen (SLA) gene is associated with the growth and development traits of swine. In this study, the partial sequence of SLA-DRB gene was sequenced for 89 Aba Tibetan pigs (Pujiang county, Sichuan province) to screen potent markers for genetic breeding, and 14 loci of single nucleotide polymorphisms were identified. Based on their linkage relationships, these 14 SNPs were allocated into 3 loci groups (loci group 1: g.11470, g.11945, g.11997, g.11387, g.11369 and g.11829; loci group 2:g.11532 and g.11838; loci group 3: g.11911 and g.11708) and 4 single polymorphic loci (g.11468, g.11440, g.11478 and g.11944). Correlation analyses were conducted between genotypes of these loci or loci groups and 14 growth traits (i.e. withers height, body length and chest circumference). The polymorphism of loci group 3 is significantly associated with 11 growth traits (FDR<0.05), including withers height, body length and chest circumference, and individuals with genotype TT/CG have smaller somatotype than others. It suggests SLA-DRB is a potent genetic marker for miniaturization selection of Tibetan pigs. The cannon bone circumference (CBC), as well as ratios of CBC to other growth traits excepting weight, are tightly associated with the polymorphism of loci group 1, loci group 2, g.11468 and g.11478 (FDR<0.001). Individuals with genotypes GGGAAC/GGGAAC at loci group 1, GT/GT at loci group 2, C/C at g.11468 and C/C at g.11478 tend to have large CBC and CBC ratios. Given that the canon bone marrow is a major site for the immune function of SLA genes, our results provided theoretical basis and potent SNP sites for CBC based swine selective breeding and disease resistance oriented genetic breeding.
CopyRight©2018 Editorial Office of Sichuan Journal of Zoology