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Issue:ISSN 1000-7083
          CN 51-1193/Q
Director:Sichuan Association for Science and Technology
Sponsored by:Sichuan Society of Zoologists; Chengdu Giant Panda Breeding Research Foundation; Sichuan Association of Wildlife Conservation; Sichuan University
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Dynamics of brain compexity during anesthesia-awakening cycle in Xenopus laevis
Author of the article:LIU Yansu, FAN Yanzhu, FANG Guangzhan
Author's Workplace:Sichuan Nursing Vocational College;Chengdu Institute of Biology, Chinese Academy of Sciences
Key Words:general anesthesia; Electroencephalogram (EEG); thalamus; Lempel-Ziv complexity (LZC); lateralization; Xenopus laevis
Abstract:General anesthesia is a situation with drug-induced inhibition of central nervous system, under which long-term operation procedures and invasive experiments could be conducted. The thalamo-cortical loop especially the thalamus is supposed to play a role in anesthesia-awakening regulation, however, whether the thalamus is the most important brain region and this regulation is asymmetric remain unclear. The present study used South African Clawed frog (Xenopus laevis) as an animal model, and that six cortical electrode pairs were implanted on the frog skull: both sides of the telencephalon, diencephalon and mesencephalon respectively. The Frogs were immersed in triciane methanesulfonate (MS-222) for general anesthesia and the Electroencephalogram (EEG) signals were recorded for “pre-anesthesia, administration, recovery and post-anesthesia” cycle continuously. Lempel-Ziv complexity (LZC) was calculated for each stage. The results showed that LZC values differed significantly among various stages, with the highest values occurring during the awakening period and the lowest values during the anesthesia period; and that significant correlations between the duration of administration stage and LZC values were found exclusively for the right hemisphere, especially for the right thalamus. These results suggested that anesthesia-awakening cycle could be reflected by LZC and the right thalamus might play an important role in anesthesia-awakening regulation.
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