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Issue:ISSN 1000-7083
          CN 51-1193/Q
Director:Sichuan Association for Science and Technology
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Gene Cloning, Molecular Evolution and Tissue Expression of G Protein-coupled Receptor 161 in Chicken
Author of the article:ZHU Guoqiang, MO Chunheng, LI Zhengyang, WANG Yajun, LI Juan
Author's Workplace:Key Laboratory of Bio-resources and Eco-environment of Ministry of Education, College of Life Sciences, Sichuan University, Chengdu 610065, China
Key Words:chicken; GPR161; gene cloning; molecular evolution; tissue expression
Abstract:G protein-coupled receptor 161 (GPR161), as a member of GPCR, is an orphan receptor, playing important role in the lens development and neurulation. Owing to its sharing similar structure as scaffolding proteins, GPR161 draws wide attention for its potential in signal transduction. Using chicken as experimental model, the cDNA sequence, molecular evolution and tissue expression of chicken GPR161 gene were reported in the present study. The full-length coding sequence of chicken GPR161 gene is 1 566 bp in length encoding 521 amino acids. Sequence analysis revealed that GPR161 of chicken shares high sequence similarity with that of human (83.0%), mouse (82.6%) or zebrafish (65.8%). Molecular evolutionary genetical analysis of GPR161 shows that relations between chicken and human or mouse are closer than that of chicken and zebrafish. By real-time quantitative PCR, the mRNA of GPR161 is expressed with high abundance in testis or ovary, brain, heart and muscle. Our data provides basis for the revealization of GPR161 gene’s physiological role in birds.
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