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Issue:ISSN 1000-7083
          CN 51-1193/Q
Director:Sichuan Association for Science and Technology
Sponsored by:Sichuan Society of Zoologists; Chengdu Giant Panda Breeding Research Foundation; Sichuan Association of Wildlife Conservation; Sichuan University
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Comparison of mRNA levels of PPP2CA and PME-1 genes in the testes of yaks and sterile cattle-yaks
Author of the article:REN Liang, FU Wei, JIN Suyu, HUANG Lin, LI Caixia,
Author's Workplace:1 College of Life Science and Technology, Southwest University for Nationalities;2 Jiange Animal Disease Control and Prevention Centre
Key Words: yak; cattle-yak; hybrid male sterility; protein phosphatase 2A; protein methylesterase 1
Abstract:Protein phosphatase 2A (PP2A) participates in the protein reversible phosphorylation, and plays a central role in phosphorylation-dependent signaling pathways. Its activity is regulated by protein methylesterase 1 (PME-1) and other factors. To elucidate the molecular mechanism of hybrid male sterility of yaks, this study cloned cDNA sequences of catalytic subunit α (PPP2CA) of PP2A and PME-1 genes. The coding regions of yak PPP2CA and PME-1 genes are 930 bp and 1143 bp, respectively. The deduced animo acid sequences are conserved. Quantative PCR assay showed that cattle-yaks (n=7) contained dramatically reduced mRNA levels of PPP2CA and PME-1 genes in testes than yaks (n=13, P<0.01). The present results suggest that the reduced mRNA levels of the two genes in the testes might influence some important signaling pathways and associate with hybrid male sterility of cattle-yaks.
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