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内侧杏仁核中催产素对布氏田鼠社会行为的影响
Effect of Oxytocin in the Medial Amygdala on the Social Behavior of Lasiopodomys brandtii
张楠, 闫立新, 高杰, 孙秀萍, 宋铭晶*
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DOI:10.11984/j.issn.1000-7083.20160288
作者单位:中国医学科学院医学实验动物研究所, 北京协和医学院比较医学中心, 卫生部人类疾病比较医学重点实验室, 北京 100021
中文关键字:布氏田鼠;催产素;杏仁核;社会记忆;亲社会性
英文关键字:Lasiopodomys brandtii; oxytocin; medial amygdala; social memory; prosocial
中文摘要:目的 探究内侧杏仁核(MeA)脑区中催产素(OT)对布氏田鼠Lasiopodomys brandtii社会行为的影响。方法 在雄性布氏田鼠MeA区注射催产素受体拮抗剂后,采用社会识别实验、中央竞技场实验确定MeA区催产素受体的变化对其社会行为的影响。结果 社会识别实验发现在MeA区注射人工脑脊液的布氏田鼠(对照组)对陌生鼠的探索时间显著长于探索熟悉鼠(0.001 < P < 0.01),而在MeA区注射催产素受体拮抗剂(实验组)对熟悉鼠和陌生鼠探索时间的差异无统计学意义(P>0.05),实验组对空笼、刺激鼠以及陌生鼠的探索时间都显著少于对照组(0.01 < P < 0.05);中央竞技场实验中实验组的攻击潜伏期和攻击时长与对照组的差异无统计学意义(P>0.05)。结论 MeA区中OT对布氏田鼠的社会记忆能力有影响,从而造成其社会识别障碍,但是对其社会性偏好和攻击行为都没有影响,说明OT在MeA区的表达是通过影响布氏田鼠的社会记忆进而影响其社会行为,而非改变布氏田鼠的亲社会性。
英文摘要:Objective To explore the influence of oxytocin (OT) in the medial amygdala (MeA) on the social behaviors of Brandt's voles (Lasiopodomys brandtii). Methods Oxytocin receptor antagonist (OTRA) was injected into the MeA of male Brants's voles, and then the social behaviors were tested using social recognition experiment and neutral arena encounter experiment. Results The control group (injected with artificial cerebrospinal fluid) took more time to explore the strangers than the familiars (0.001 < P < 0.01). However, the experimental group took the similar time to investigate the strangers and the familiars (P>0.05). And the experimental group spent significantly less time on empty cage, stimulus and strangers than that of the control group (0.01 < P < 0.05). The experimental group showed similar attack time and incubation time of attack than the control (P>0.05). Conclusion OT in MeA can influence the social recognition and memory ability of the Brandt's voles, but cannot affect its attack behavior. Therefore, it was concluded that the expression of OT in MeA could affect Brandt's voles' social behavior by impairing the ability of social memory, rather than changing their prosocial ability.
2017,36(2): 193-197 收稿日期:2016-10-21
DOI:10.11984/j.issn.1000-7083.20160288
分类号:Q959.837;Q95-33
基金项目:国家自然科学基金项目(31301890);农业虫害鼠害综合治理研究国家重点实验室开放研究基金项目(Chinese IPM1615)
作者简介:张楠(1991-),男,硕士研究生,主要从事实验动物学研究
*通讯作者:宋铭晶,E-mail:songmj@cnilas.org
参考文献:
李广宇. 2012. 配偶选择对黑线仓鼠脑内Dadr2表达的影响[D]. 山东曲阜:曲阜师范大学.
孟雅婧, 杨洋, 刘莹, 等. 2014. 催产素受体配体及其中枢和外周功能研究进展[J]. 中国药理学通报, (6):752-756.
张健旭, 张知彬, 王祖望. 1999. 大仓鼠在繁殖期的行为关系及交配行为[J]. 兽类学报, (2):52-55.
Arakawa H, Arakawa K, Deak T. 2010. Oxytocin and vasopressin in the medial amygdala differentially modulate approach and avoidance behavior toward illness-related social odor[J]. Neuroscience, 171(4):1141-1151.
Cao Y, Wu R, Tai F, et al. 2014. Neonatal paternal deprivation impairs social recognition and alters levels of oxytocin and estrogen receptor alpha mRNA expression in the MeA and NAcc, and serum oxytocin in mandarin voles[J]. Hormones & Behavior, 65(1):57-65.
Ferguson JE, Head BH, Frank FH, et al. 2002. Misoprostol versus low-dose oxytocin for cervical ripening:a prospective, randomized, double-masked trial[J]. American Journal of Obstetrics and Gynecology,187(2):273-280.
Liu Y, Fowler CD, Wang Z. 2001. Ontogeny of brain-derived neurotrophic factor gene expression in the forebrain of prairie and montane voles[J]. Developmental Brain Research, 127(1):51-61.
Olazabal DE, Young LJ. 2006. Oxytocin receptors in the nucleus accumbens facilitate "spontaneous" maternal behavior in adult female prairie voles[J]. Neuroscience, 141(2):559-568.
Page DT, Kuti OJ, Sur M. 2009. Computerized aassessment of social approach behavior in mouse[J]. Frontiers in Behavioral Neuroscience,3:48.
Pan Y, Liu Y, Lieberwirth C, et al. 2016. Species differences in behavior and cell proliferation/survival in the adult brains of female meadow and prairie voles[J]. Neuroscience, 315:259-270.
Pan Y, Xu L, Young KA, et al. 2010. Agonistic encounters and brain activation in dominant and subordinate male greater long-tailed hamsters[J]. Hormones and Behavior, 58(3):478-484.
Penagarikano O, Lazaro MT, Lu XH, et al. 2015. Exogenous and evoked oxytocin restores social behavior in the Cntnap2 mouse model of autism[J]. Science Translational Medicine, 7(271):271r-278r.
Shen H. 2015. Neuroscience:the hard science of oxytocin[J]. Nature, 522(7557):410-412.
Wang B, Li Y, Wu R, et al. 2015. Behavioral responses to pups in males with different reproductive experiences are sssociated with changes in central OT, TH and OTR, D1R, D2R mRNA expression in mandarin voles[J]. Hormones & Behavior, 67:73-82.
Wang D, Li D, Liu M, et al. 2011. Behavioral evaluation of quinestrol as a sterilant in male Brandt's voles[J]. Physiology & Behavior, 104(5):1024-1030.
Wang Y, Xu L, Pan Y, et al. 2013. Species differences in the immunoreactive expression of oxytocin, vasopressin, tyrosine hydroxylase and estrogen receptor alpha in the brain of mongolian gerbils (Meriones unguiculatus) and Chinese striped hamsters (Cricetulus barabensis)[J]. PLoS ONE, 8(6):e65807. DOI:10.1371/journal.pone.0065807.
Winslow JT. 2003. Mouse social recognition and preference[J]. Current Protocols in Neuroscience, 8:8-16.
Xu L, Pan Y, Young KA, et al. 2010. Oxytocin and vasopressin immunoreactive staining in the brains of Brandt's voles (Lasiopodomys brandtii) and greater long-tailed hamsters (Tscherskia triton)[J]. Neuroscience, 169(3):1235-1247.
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